The Bill Priest Institute is home to the headquarters for the North Texas Small Business Development Center, which oversees the operation of 17 SBDCs throughout the 49-county North Texas area. The following SBDCs are hosted by DCCCD entities in partnerships with the SBA:
- Best Southwest SBDC, located at Cedar Valley College
- Dallas SBDC, located at the Bill Priest Institute
- Risk Management SBDC, located at the Bill Priest Institute
- International SBDC, located at the World Trade Center, hosted by the Bill Priest Institute
- Government Contracting SBDC, located at the Bill Priest Institute
- Technology Assistance SBDC, located at the Bill Priest Institute